Canadian Pharmacist Evaluating Examination (PEBC)

If the pKa of phenobarbital is 7.4, what approximate fraction of the drug would be ionized at pH 8.4?

In an adequately powered, randomized controlled trial conducted over 3 years, a specific serious side effect (i.e., reduction in leukocytes) with conventional therapy is seen in 0.5% of the study sample. In patients who receive a newly discovered drug, only 0.45% experience the same side effect. Based on these results, the minimum number of patients that would have to receive the new drug for 3 years to statistically demonstrate the prevention of one episode of this side effect in at least one patient is:

. A patient has a Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. Of the following drugs, which should be avoided in this patient?

Which of the following drugs is contraindicated in a 25-year-old female taking oral contraceptives?

For which of the following conditions would QVAR be indicated?
I. COPD
II. Asthma
III. Tuberculosis

Which of the following may be used as an antidote to benzodiazepine overdose?
I. Flumazenil
II. Nalmefene
III. Physostigmine
IV. Protamine

A patient is on iron supplements. They ask if they should take it with food. Your response is:

Which of the following statement about sufentanil is untrue?

When discussing antibiotic treatment (Amoxicillin, 500 mg, PO, tid) with a patient, which of the following is true?
I. There are no interactions to be concerned about with Amoxicillin.
II. If a patient is on oral contraceptives, it is strongly suggested a backup means of contraception is used.
III. If a patient is on oral contraceptives, it is strongly suggested that they stop using the contraceptives immediately.
IV. Taking oral contraceptives along with Amoxicillin is fine as long as you double up on the oral contraceptive.

A patient diagnosed with PCOS (Polycystic Ovarian Syndrome) is prescribed clomiphene citrate. What would you tell her about the primary side effects?